Even after his death, the power of Hashirama’s cells became a coveted resource. Shinobi like Orochimaru, Madara Uchiha, and Danzo exploited his DNA to amplify their abilities, achieve immortality, or gain unmatched power. Madara, for instance, awakened the Rinnegan by integrating Hashirama’s cells, while Orochimaru created Yamato, a clone capable of wielding Wood Release.